Investigation of the properties of magnetocaloric Mn1-xFexNiGe (0.05 ≤ x ≤ 0.30) films

MnNiGe-based solid solutions are currently positioned as “green” magnetocaloric materials, promising for use in magnetic refrigerators [1-3]. The magnetic behavior of the MnNiGe system is strongly dependent on doping, special heat treatment, pressure imposition, etc. One of the most important factors determining the magnetic behavior of the system is the state of the sample - film or massive. Твердые растворы на основе MnNiGe в настоящее время позиционируются как «зеленые» магнитокалорические материалы, перспективные для использования в магнитных холодильниках [1-3]. Магнитное поведение системы MnNiGe сильно зависит от легирования, специальной термообработки, давления и т. Д. Одним из наиболее важных факторов, определяющих магнитное поведение системы, является состояние образца - пленки или массива

Giant Terahertz Photoconductance of Quantum Point Contacts in the Tunneling Regime

We report on the observation of the giant photoconductance of a quantum point contact (QPC) in the tunneling regime excited by terahertz radiation. Studied QPCs are formed in a GaAs/(Al, Ga) As heterostructure with a high-electron-mobility two-dimensional electron gas. We demonstrate that irradiation of strongly negatively biased QPCs by laser radiation with frequency f = 0.69 THz and intensity 50mW/cm(2) results in two orders of magnitude enhancement of the QPC conductance. The effect increases with the dark conductivity decrease. It is also characterized by a strong polarization dependence and a drastic reduction of the signal by increasing the radiation frequency to 1.63 THz. We demonstrate that all experimental findings can be well explained by the photon-assisted tunneling through the QPC. Corresponding calculations are in good agreement with the experiment

High frequency of BRCA1, but not CHEK2 or NBS1 (NBN), founder mutations in Russian ovarian cancer patients

<p>Abstract</p> <p>Background</p> <p>A significant portion of ovarian cancer (OC) cases is caused by germ-line mutations in BRCA1 or BRCA2 genes. BRCA testing is cheap in populations with founder effect and therefore recommended for all patients with OC diagnosis. Recurrent mutations constitute the vast majority of BRCA defects in Russia, however their impact in OC morbidity has not been yet systematically studied. Furthermore, Russian population is characterized by a relatively high frequency of CHEK2 and NBS1 (NBN) heterozygotes, but it remains unclear whether these two genes contribute to the OC risk.</p> <p>Methods</p> <p>The study included 354 OC patients from 2 distinct, geographically remote regions (290 from North-Western Russia (St.-Petersburg) and 64 from the south of the country (Krasnodar)). DNA samples were tested by allele-specific PCR for the presence of 8 founder mutations (BRCA1 5382insC, BRCA1 4153delA, BRCA1 185delAG, BRCA1 300T>G, BRCA2 6174delT, CHEK2 1100delC, CHEK2 IVS2+1G>A, NBS1 657del5). In addition, literature data on the occurrence of BRCA1, BRCA2, CHEK2 and NBS1 mutations in non-selected ovarian cancer patients were reviewed.</p> <p>Results</p> <p>BRCA1 5382insC allele was detected in 28/290 (9.7%) OC cases from the North-West and 11/64 (17.2%) OC patients from the South of Russia. In addition, 4 BRCA1 185delAG, 2 BRCA1 4153delA, 1 BRCA2 6174delT, 2 CHEK2 1100delC and 1 NBS1 657del5 mutation were detected. 1 patient from Krasnodar was heterozygous for both BRCA1 5382insC and NBS1 657del5 variants.</p> <p>Conclusion</p> <p>Founder BRCA1 mutations, especially BRCA1 5382insC variant, are responsible for substantial share of OC morbidity in Russia, therefore DNA testing has to be considered for every OC patient of Russian origin. Taken together with literature data, this study does not support the contribution of CHEK2 in OC risk, while the role of NBS1 heterozygosity may require further clarification.</p

CATMoS: Collaborative Acute Toxicity Modeling Suite.

BACKGROUND: Humans are exposed to tens of thousands of chemical substances that need to be assessed for their potential toxicity. Acute systemic toxicity testing serves as the basis for regulatory hazard classification, labeling, and risk management. However, it is cost- and time-prohibitive to evaluate all new and existing chemicals using traditional rodent acute toxicity tests. In silico models built using existing data facilitate rapid acute toxicity predictions without using animals. OBJECTIVES: The U.S. Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) Acute Toxicity Workgroup organized an international collaboration to develop in silico models for predicting acute oral toxicity based on five different end points: Lethal Dose 50 (LD50 value, U.S. Environmental Protection Agency hazard (four) categories, Globally Harmonized System for Classification and Labeling hazard (five) categories, very toxic chemicals [LD50 (LD50≤50mg/kg)], and nontoxic chemicals (LD50>2,000mg/kg). METHODS: An acute oral toxicity data inventory for 11,992 chemicals was compiled, split into training and evaluation sets, and made available to 35 participating international research groups that submitted a total of 139 predictive models. Predictions that fell within the applicability domains of the submitted models were evaluated using external validation sets. These were then combined into consensus models to leverage strengths of individual approaches. RESULTS: The resulting consensus predictions, which leverage the collective strengths of each individual model, form the Collaborative Acute Toxicity Modeling Suite (CATMoS). CATMoS demonstrated high performance in terms of accuracy and robustness when compared with in vivo results. DISCUSSION: CATMoS is being evaluated by regulatory agencies for its utility and applicability as a potential replacement for in vivo rat acute oral toxicity studies. CATMoS predictions for more than 800,000 chemicals have been made available via the National Toxicology Program's Integrated Chemical Environment tools and data sets (ice.ntp.niehs.nih.gov). The models are also implemented in a free, standalone, open-source tool, OPERA, which allows predictions of new and untested chemicals to be made. https://doi.org/10.1289/EHP8495

Electromagnetic Field Interaction With Transmission Lines: From Classical Theory to HF Radiation Effects

The evaluation of the electromagnetic field coupling to transmission lines is an important problem in electromagnetic compatibility. The unabated increase in the operating frequency of electronic products and the emergence of sources of disturbances with higher frequency content (such as High Power Microwave and Ultra-Wide Band systems) have led to a breakdown of the TL approximation's basic assumptions for a number of applications. In the last decade or so, the generalization of the TL theory to take into account high frequency effects has emerged as an important topic of study in electromag